RRs (95% CI) off complete, ischemic, and you will hemorrhagic shots by quintiles out of mutual diet score to possess magnesium, potassium, and you can calcium supplements consumption inside 86,149 women in the NHS We and you can 94,715 ladies in brand new NHS II step 1
I current new meta-analyses away from possible studies away from losing weight magnesium ( 21), potassium ( 22), and you can calcium ( 23) intakes and you will chance of heart attack
The multivariate model was adjusted for age, calendar year, total calories (quintiles of kcal), BMI (in kg/m 2 ; <25, 25 to <30, or ?30), parental history of heart disease (aged ?60 y), alcohol intake (0, 0 to <5, 5 to <10, 10 to <15, or ?15 g/d), physical activity (<3, 3 to <9, 9 to <18, 18 to <27, or ?27 metabolic equivalent tasks/wk), smoking, postmenopausal hormone therapy, oral contraceptive use (never, past, or current), menopausal status (premenopausal or postmenopausal), aspirin (0 to <2 or ?2 pills/wk), multivitamin, history of hypertension, hypercholesterolemia, diabetes at baseline, and thiazide use (yes or no). NHS, Nurses’ Health Study.
RRs (95% CI) away from complete, ischemic, and you will hemorrhagic shots by the quintiles regarding joint diet plan scores getting magnesium, potassium, and you will calcium supplements intakes from inside the 86,149 women in the NHS I and you will 94,715 ladies in the fresh new NHS II step one
I current the newest meta-analyses from potential knowledge out-of weight reduction magnesium ( 21), potassium ( 22), and calcium supplements ( 23) intakes and you can danger of coronary attack
The multivariate model was adjusted for age, calendar year, total calories (quintiles of kcal), BMI (in kg/m 2 ; <25, 25 to <30, or ?30), parental history of heart disease (aged ?60 y), alcohol intake (0, 0 to <5, 5 to <10, 10 to <15, or ?15 g/d), physical activity (<3, 3 to <9, 9 to <18, 18 to <27, or ?27 metabolic equivalent tasks/wk), smoking, postmenopausal hormone therapy, oral contraceptive use (never, past, or current), menopausal status (premenopausal or postmenopausal), aspirin (0 to <2 or ?2 pills/wk), multivitamin, history of hypertension, hypercholesterolemia, diabetes at baseline, and thiazide use (yes or no). NHS, Nurses' Health Study.
We examined separately the relation between intakes of magnesium, potassium, and calcium from supplements and risk of stroke. There was no significant association between supplemental magnesium or calcium intake and risk of total, ischemic, or hemorrhagic stroke in the pooled analyses. We observed a significant inverse association between supplemental potassium intake and risk of ischemic but not total or hemorrhagic stroke. The pooled multivariate RR for comparison of highest with lowest quintiles of supplemental potassium intake was 0.71 (95% CI: 0.56, 0.89, P-trend < 0.01) for ischemic stroke. Pooled multivariate RRs for supplemental magnesium (Supplemental Table 7), supplemental potassium (Supplemental Table 8), and supplemental calcium (Supplemental Table 9) and risk of total, ischemic, and hemorrhagic strokes are shown in the supplemental material.
We examined total and you will fat loss intakes of each nutrient and you may exposure out-of coronary attack to determine any possible nonlinear organization that with limited cubic splines; but not, no significant departure from linearity is seen. At exactly the same time, i looked the potential impression amendment from the decades, blood circulation pressure, or diabetes to your relatives ranging from total intake of all the 3 nutritional elements and you will danger of full heart attack. Zero tall impact modification was observed of the these types of circumstances.
Prior meta-analyses provided is a result of earlier analyses throughout the NHS ( 10); this type of overall performance have been replaced from the results in the present day research. At the same time, the new literature was checked, and you can previous potential degree ( 8, 24) were used in such current meta-analyses. Zero between-knowledge heterogeneity try seen for the of the step 3 nutritional elements. The fresh combined RR from full stroke is actually 0.87 (95% CI: 0.83, 0.92) to own a hundred-mg/d raise out-of magnesium consumption, 0 https://datingranking.net/std-dating-sites/.91 (95% CI: 0.88, 0.94) to possess good a lot of-mg/d improve out of potassium intake, and you may 0.98 (95% CI: 0.94, step 1.02) to own a 3 hundred-mg/d improve from calcium supplements intake.